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29 .   An evaluation of three nutraceutical species in the Apiaceae family from the Western part of Romania: antiproliferative and antiangiogenic potential

Authors: Corina Danciu, Ştefana Avram, Pusa Gaje, Georgeta Pop, Codruţa Şoica, Marius Craina, Cătălin Dumitru, Cristina Dehelean, Camelia Peev

Volume 19, Issue 2;
Pages: 173-179;
ISSN: 2069-0053 (print) (former ISSN: 1453-1399), Agroprint;
ISSN (online): 2068-9551



Abstract:

The Apiaceae Family provides a large number of plants that can be used for both medicinal and alimentary purpose and are also called nutraceutical plants. Several species in this family are good sources for phytocompounds with antiprolifferative properties, among whom apigenin and quercetin We aimed to investigate a possible antiproliferative and antiangiogenic effect of some representatives from the Apiaceae Family cultivated in the Western part of Romania, namely Levisticum officinale Koch (lovage), Petroselinum hortense Hoffm. (parsley) and Apium graveolens L. (celery). On this purpose phyto biological test and the the chorioallantoic membrane assay (CAM assay) were performed. From the point of view of inhibitory effect on germination, the total vegetal extract from all the three Apiaceae species corresponding to the mentioned parts of the plant can be taken in consideration for the next stage for the concentrations of 3% , 1,5%, 0,75% and 0,38% total vegetal extract. From the three species it seems that Levisticum officinale Koch is the most active in terms of inhibition of germination of garden cress . In terms of an antiangiogenic effect the most active extract was that of Petroselinum hortense Hoffm , followed by that of Levisticum officinale Koch . The three nutraceutical plants considered as health promoters can represent sources of extracts or active compounds for the use as antiprolifferative therapeutics, especially lovage flowers and leaves, or on excessive angiogenesis, in particular, the parsley leaves.

Keywords: Levisticum officinale Koch, Petroselinum hortense Hoffm., Apium graveolens L.,nutraceutical, phytobiological test, chorioallantoic membrane

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